Natural Treatments For Ebola Virus Exist, Research Suggests

Natural Treatments For Ebola Virus Exist, Research Suggests | ebola_virus_therapy-460x287 | Natural Medicine

Fear of infection with the Ebola virus is becoming as contagious as the virus itself, with mainstream media outlets like CNN reporting, ‘Ebola outbreak could have ‘catastrophic’ consequences.’

Given the prevailing mortality statistics, perhaps the fear is, at least partially, justified, with the most virulent form of the virus – the Zaire Ebola virus – observed to have a fatality rate of about 83%,[1] and with no officially recognized conventional or natural therapy found capable of mitigating morbidity and mortality associated with infection from it.

There are actually five Ebola viruses in the Ebolavirus genus,[2] with four of them known to infect humans causing Ebola virus disease, a highly lethal form of hemorrhagic fever. Ebola virus infection is believed to originate from either monkeys or fruit bats, and once a human is infected, transmission can occur through blood or bodily fluids, sexual intercourse,[3] and as a recent concerning investigative report revealed, through the air.

While the conventional medical system reflexively puts its faith and money into drug and vaccine development, with NIH recently announcing it will begin an early trial on Ebola vaccines this September of this year, very little research has been performed on reducing risk, or mitigating post-infection harm, with the use of time-tested, natural immune-boosting and/or plant-based approaches. Given the low safety risk and cost of botanical- and food-based interventions, this is where we should be looking first for viable, and immediately accessible solutions. Indeed, a recent study published in 2012 holds great promise as far as identifying a natural way to mitigate the virulence – and therefore also widespread fear — associated with Ebola virus.

Published in the journal Archives of Virology and titled, “Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin,” researchers at the University of Texas Medical Branch, investigated the potential therapeutic role of two so-called ‘kinase inhibitors’ in interfering with Ebola virus: 1) the plant compound genistein 2) the pharmaceutical drug tyrophostin.

The authors reference a previous animal study showing genistein was able to reduce harm from infection from a virus that causes an Ebola-like viral hemorrhagic fever (VHF) in hamsters (namely, Pichinde ́virus (PICV)), reporting the results as follows:

“Infection of hamsters with PIRV produces VHF manifestations, including inflammation/lesions in various organs, core temperature increase, weight loss, viremia, petechial rash, hemorrhage, and mortality. Treating the animals with the kinase inhibitor genistein led to a significant increase in survival and to the amelioration of VHF disease signs [9]. None of the treated mock-infected animals had any adverse signs of disease associated with the treatment. Therefore, this study served as a proof-of-concept for using a kinase inhibitor as a therapeutic or prophylactic in an animal model.” [emphasis added]

The researchers sought to identify genistein and tyrophostin’s ability to inhibit viral entry of various viruses known to cause hemorrhagic fever, including Ebola, Marburg virus (MARV), Vesicular Stomatis virus (VSV) and Lassa virus (LASV). Proteins from these four viruses were engineered to be expressed by a special type of virus, known as vesicular stomatitis virus (VSV).

The study found both genistein and tyrophostin individually inhibit the entry of these viruses into the cells, both through interfering with endocytosis (the process by which a cell pulls in a virus) and uncoating proteins (the process by which a virus alters proteins on the surface of the host cell to gain entry). It was also observed that a synergistic effect occurred when genistein and tyrophostin were added together.

The researchers discussed their findings:

“In all, these data demonstrate that infection of host cells with the filoviruses MARV and EBOV and the arenavirus LASV is inhibited when cells are pretreated with genistein or tyrphostin AG1478. In both cases, the inhibition was found to be concentration dependent. Although the inhibition of EBOV in cells pre-treated with 100 lM genistein appeared to differ slightly, the addition of increasing concentrations of tyrphostin AG1478 led to a synergistic antiviral effect. In all, these data demonstrate that a kinase inhibitor cocktail consisting of genistein and tyrphostin AG1478 may act as a broad antiviral against EBOV, MARV, and LASV in vitro.”

Where Does Genistein Come From?

While primarily found in soy products, especially fermented soy foods, wherein beneficial microbes cause the biotransformation of the precursor phytocompund genistin into genistein, it is also found in fava beans, kudzu, coffee and red clover, and many other lesser known medicinal plants.

What Else Does Genistein Do?

At Greenmedinfo.com we have indexed over 150 health benefits of genistein, across 50 mapped physiological pathways, that have been identified in the biomedical literature. You can view them here: Evidence-Based Genistein Benefits. It is interesting to note that genistein’s wide spectrum antiviral properties have already been identified. A 2009 review,[4] in fact, stated:

“Genistein is, by far, the most studied soy isoflavone in this regard, and it has been shown to inhibit the infectivity of enveloped or nonenveloped viruses, as well as single-stranded or double-stranded RNA or DNA viruses. At concentrations ranging from physiological to supraphysiological (3.7-370 muM), flavonoids, including genistein, have been shown to reduce the infectivity of a variety of viruses affecting humans and animals, including adenovirus, herpes simplex virus, human immunodeficiency virus, porcine reproductive and respiratory syndrome virus, and rotavirus.”

What are Other Potential Natural Therapeutics for Ebola?

First, it must be pointed out that, historically, Ebola virus outbreaks occur in some of the most impoverished places on Earth (primarily the poorest regions of Africa), among populations chronically malnourished, traumatized by sociopolitical unrest and wars, and where modern day sanitation, hygiene practices, and adequate nutrition, are available suboptimally, to say the least.  In other words, the mainstream media’s prediction of a so-called ‘catastrophic’ outbreak in the US and other wealthier countries does not seem to take into account the differing contexts that makes infections like these possible to begin with, with the ‘inner terrain,’ i.e. immune status of the host, fundamental in determining the degree to which an individual becomes susceptible to infection.

With that said, Ebola does appear to be a uniquely pathogenic virus to which the human body has yet had adequate time to properly adapt, and therefore it is instructive to point other potential natural therapies that have been studied in the past:

  • Garcinia kola: As reported in 1999, extracts from the seeds of this traditional African medicinal herb were found to”…inhibit this virus [Ebola] in cell culture at non-toxic concentrations.”
  • Homeopathic interventions: A study published in 1999 explored the therapeutic potential of a homeopathic preparation of the six-eyed spider venom (Sicarius) at treating symptoms associated with Ebolavirus infection.[5]
  • Estradiol: A 2013 analysis, titled “A systematic screen of FDA-approved drugs for inhibitors of biological threat agents,” found that estradiol exhibited anti-Ebola virus activity in vitro, indicating the relevance of hormonal factors and perhaps gender in susceptibility to the disease – as well as a possible therapeutic role for estradiol if future clinical research confirms bears these findings out.

This is only a small sampling, and the fact is that very little research has been performed in this area. There are a wide range of natural compounds that have yet to be evaluated for their direct anti-Ebola activity and/or immune boosting properties, and that may be highly relevant to the goal of preventing and curing it. The most important consideration is that no infection – including highly lethal ones like Ebola – occurs in a vacuum.  Psychological, biological, environmental and sociopolitical factors all determine the incidence, spread and virulence of viral infections. Therefore, in the absence of any known drug- or vaccine-based method to prevent or reduce harm from Ebola infection, the aforementioned research and ‘environmental’ considerations may provide future hope and direction for addressing epidemics of this kind. This is especially important considering how profoundly fearful folks have become at the specter of diseases they do not understand — fears which contribute to immunosuppression and therefore may contribute to the self-fulfilling prophecy associated with belief in Ebola’s extreme lethality.

References

[1] Isaacson, M; Sureau, P; Courteille, G; Pattyn, SR;. Clinical Aspects of Ebola Virus Disease at the Ngaliema Hospital, Kinshasa, Zaire, 1976. Retrieved 2009-07-08.

[2] Kuhn, J. H.; Becker, S.; Ebihara, H.; Geisbert, T. W.; Johnson, K. M.; Kawaoka, Y.; Lipkin, W. I.; Negredo, A. I.; Netesov, S. V.; Nichol, S. T.; Palacios, G.; Peters, C. J.; Tenorio, A.; Volchkov, V. E.; Jahrling, P. B. (2010). “Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations”. Archives of Virology 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. PMC 3074192. PMID 21046175.

[3] “Ebola virus disease Fact sheet N°103”. World Health Organization. March 2014. Retrieved 12 April 2014.

[4] Aline Andres, Sharon M Donovan, Mark S Kuhlenschmidt. Soy isoflavones and virus infections. J Nutr Biochem. 2009 Aug;20(8):563-9. PMID: 19596314


Article Contributed by Sayer Ji, Founder of www.GreenMedInfo.com

Sayer Ji is an author, researcher, lecturer, and advisory board member of the National Health Federation. He founded Greenmedinfo.com in 2008 in order to provide the world an open access, evidence-based resource supporting natural and integrative modalities. It is internationally recognized as the largest and most widely referenced health resource of its kind.

 

About The Author

Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.

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    • sharpstuff

      And the winner of the lottery for pandemics this year is…the Ebola virus!

      More nonsense from the cretinati. Show me a virus of any description and I will give you the World. There are NO germs or viruses. All diseases are caused by some form of malnutrition (physical or not physical).

      Oh, and vaccines don’t work, they only maim and kill.

    • Olajuwon Okubena

      I have watched with dismay, the panic and stress associated with fear of contacting the Ebola Virus Disease. Its effect on the medical
      community is also scary as they too can get infected with the disease. However, there is a need to re-think what is currently being done, i.e. identify, isolate, quarantine and medicate. This is because we have to tackle the spread of this disease in a multi dimensional manner.
      My recommended approach is as stated below:
      1. Stop the spread of the disease
      A paper titled “Role of Natural Killer Cells in Innate
      Protection against Lethal Ebola Virus Infection” published in 2004 in The Journal of Experimental Medicine Volume 200, Number 2, July 19, 2004 169–179 [http://www.jem.org/cgi/doi/10.1084/jem.20032141]
      written by Kelly L. Warfield [United
      States Army Medical Research Institute of Infectious Diseases], Jeremy G. Perkins [Department of Hematology and Oncology, Walter Reed Army Medical Center, Washington DC 20307],
      Dana L. Swenson [United States Army Medical Research Institute of Infectious Diseases], Emily M. Deal [United States Army Medical Research Institute of Infectious Diseases], Catharine M. Bosio
      [Clinical Research Management], M. Javad Aman [Clinical Research Management], Wayne M. Yokoyama [Howard Hughes Medical Institute, Rhuematology Division, Washington University School of Medicine, St. Louis, MO 63110], Howard A. Young [Laboratory of Experimental Immunology, National Cancer Institute, Frederick, Maryland 21702] and Sina Bavari [United States Army
      Medical Research Institute of Infectious Diseases] stated in its abstract that
      “These findings revealed a decisive role for NK cells during lethal Ebola virus infection” and the principle is the inhibiting of the replication of the virus within the human body.
      We have to do whatever we can to stop new cases of infection. This can be achieved by both the activation and strengthening of the NK Cells within the human body so that the immune system can fight the virus.
      Like the method that Field Marshal Erwin Rommel opined for defeating the Allies during the Second World War, the time to defeat the invasion force was when it first hit the beaches. To
      that end he worked to have the strongest units stationed along the coastline and built coastal batteries and strong points, augmented by thousands of anti-invasion obstacles and millions of mines.

      We, today, have to do something similar for the human body. We have to augment our innate immune systems to be battle ready for the Ebola Virus. After all, if the Ebola Virus is unable to replicate itself effectively, it will not cause any visible symptoms in the
      infected person and with time, the person’s immune system will kill the Ebola virus.
      The paper stated that “The identification of NK cells as
      critical mediators of early protection against Ebola virus infection are an important step forward in the identification of prophylactic and therapeutic interventions against filovirus and other incapacitating acute viral infections.”
      A prophylactic intervention will prevent the spread of the disease. We need to do much more in this regard.
      However, the question then is, what can we do to strengthen
      our immune systems and/or activate the NK Cells within our body? I’ll proffer a solution at the end of this article.
      2. Identify, isolate, quarantine and medicate
      This is the approach that the medical community have been
      advocating again and again for the management of the Ebola Virus Disease. I agree with this for people that have already started showing symptoms of the disease as the infection had progressed from its early incubation stage to the dangerous infectious stage. At this point, prevention is no longer the issue as the person concerned is already dangerously infected and could lead to death.
      To this end, the use of preventive measures do not necessarily apply.
      In summary, my method for the holistic management of the Ebola Virus Disease is the emphasis on what can be done to stop the spread of the disease (primary focus – prophylactic) while the secondary focus will be on the therapeutic measures, i.e. management of already diseased persons.
      Before I proffer a solution for containing the spread of the virus, I will like to declare that I work with a company that specializes in the production of and clinical research into African folk medicine. We have a product, Jobelyn, that has been demonstrated to activate NK Cells in-vitro and has been demonstrated to increase CD4 count and T Lymphocytes in HIV+ patients.
      You can see the references below:
      1. Kathleen F. Benson, Joni L. Beaman, Boxin Ou, Ademola Okubena, Olajuwon Okubena, and Gitte S. Jensen. West African Sorghum bicolor Leaf Sheaths Have Anti-Inflammatory and Immune-Modulating Properties In Vitro. J Med Food. 2013, 1–9

      2. Godwin I. Ayuba, Gitte S. Jensen, Kathleen F. Benson,Ademola M. Okubena, and Olajuwon Okubena, Clinical Efficacy of a West African Sorghum bicolor-Based Traditional Herbal Preparation Jobelyn Shows Increased Hemoglobin and CD4 +T-Lymphocyte
      Counts in HIV + Patients THE JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE Volume 0, Number 0, 2013, pp. 1–4
      This product has been in production since 1997 and its clinical research and production methods have been improved over time in collaboration with scientists in Europe and United States of America. Its toxicity studies have already been done. It has been
      consumed by Africans and other nationalities with no side effects for over a decade. This product is readily available and it can be mass produced for any government, agency or NGO.
      What we are looking at is saving lives, lots and lots of human lives.
      We cannot value the human life, it is priceless. If we have a solution that can prevent the spread of the disease and thereby save human lives, I think, and I am sure, that the best we can do is to make this information available in a public forum so that it can be read, evaluated and people could be advised or can make
      independent decisions for the protection of their health.
      Jobelyn is currently registered as a dietary supplement in Nigeria, United States of America and Ghana.

    • peter huston

      Hello, My name is kAZAN ALICE,
      I was diagnosed of Herpes in 2014 and I have tried all
      possible means to get cure but all to no avail, until i saw a post in a
      health forum about a herbal doctor from West Africa ( Dr BOADI ) who
      prepare herbal medicine to cure all kind of diseases including Hiv
      virus, at first i doubted if it was real but decided to give it a try,
      when i contact this herbal doctor via his email, he prepared a herbal
      medicine and sent it to me , when i received this herbal medicine, he
      gave me step by instructions on how to apply it, when i applied it as
      instructed, i was cured of this deadly virus Herpes within a week of usage I
      am now free from the virus, i was tasted negative. Contact this great
      herbal doctor via his email: boadiherbalclinic@gmail.com
      or call +2348062411614 when you contact him, Good Luck


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